The (5-5) are considered favorites (-2.5) according to the point spread ahead of their game against the (4-6) on November 26, 2023, starting at 1:00 PM ET, airing on CBS. The expected point total for the matchup is set at 44. Odds & Betting LinesColts vs Buccaneers Betting Information updated as of November 22, 2023, 9:33 AM ET.FavoriteSpreadFavorite Spread OddsUnderdog Spread OddsTotalOver Total OddsUnder Total OddsColts-2.5-115-10544-108-112ADVERTISEMENT Colts vs. Buccaneers Prediction & PickPick ATS: Indianapolis (-2.5)Pick OU: Over (44)Prediction: Indianapolis 24 - Tampa Bay 20How to Watch Indianapolis vs. Tampa BayGame Date: Sunday, November 26, 2023Time: 1:00 PM ETVenue: Lucas Oil StadiumLocation: Indianapolis, IndianaTV: Watch on CBSColts vs. Buccaneers Recent MatchupsOver their Mekhi Becton Jersey last five meetings, Indianapolis has totaled three wins versus Tampa Bay.Over their last five head-to-head matchups, Indianapolis has racked up 148 points, while Tampa Bay has accumulated 123.Indianapolis Betting InfoIndianapolis has six wins in 10 games versus the spread this year.Indianapolis games this year have hit the over on six of 10 set point totals (60%).The Colts have been moneyline favorites in two other games this season, and they Brandin Echols Jersey won both.Indianapolis has yet to play a game with moneyline odds of -135 or shorter.The Colts have a 57.4% chance to win this matchup, based on the implied probability of the moneyline.Colts StatsStatAverage (Total)RankPa s yards218.1 (2,181)17Rush yards118.0 (1,180)10Points scored24.2 (242)10Pa s yards against228.8 (2,288)18Rush yards against129.7 (1,297)25Points allowed24.8 (248)26Indianapolis' Key PlayersOffenseZack Mo s has recorded 617 rushing yards (ninth in the NFL) with five touchdowns (68.6 yards per game through nine games). His 4.6 yards per attempt rank 13th in the NFL.He has also caught 16 pa ses (on 20 targets) for 123 receiving yards with one touchdown. He's averaging 13.7 receving yards and 1.8 catches per game. has pa sed for 1,721 yards, eight touchdowns and six interceptions this year. He is averaging 191.2 yards per game and 6.7 per attempt, while completing 63.7%.He has added 44 rushing yards (4.9 per game) and two touchdowns on the ground.In 10 games played, . is averaging 67.7 yards and 6.6 receptions per game to total 677 receiving yards and 66 catches. He's been targeted 98 times, and has three receiving touchdowns. averages 4.3 receptions and 52.3 yards per game, and has 523 total receiving yards and 43 catches. He's gotten 60 total targets, and has Quincy Enunwa Jersey caught two touchdown pa ses.DefenseOver on the defensive side, has 117 tackles, 2.0 TFL, and 1.5 sacks in 2023. His tackle total leads the Colts and is third in the NFL.Kenny Moore II has picked off three pases (sixth in the NFL) and has added 67 tackles, 7.0 TFL, 1.5 sacks, and five pa ses defended. has recorded 44 tackles, 7.0 TFL, and five sacks this year.So far this season, has 66 tackles, 5.0 TFL, and three interceptions. He's third on the Colts in tackles.Tampa Bay Betting InfoTampa Bay have registered a 7-3-0 record against the spread this year.The Buccaneers have an against the spread record of 5-2 in their seven games as an underdog of 2.5 points or more this season.Tampa Bay games have gone over the total twice this year.The Buccaneers have entered the game as underdogs seven times this season and won twice.Tampa Bay has a record of 2-5 in games where bookmakers have them as underdogs of at least +114 on the moneyline.Bookmakers have implied with the moneyline set for this matchup that the Buccaneers have a 46.7% chance to win.Buccaneers StatsStatAverage (Total)RankPa s yards227.8 (2,278)14Rush yards76.9 Carl Lawson Jersey (769)32Points scored19.2 (192)23Pa s yards against270.7 (2,707)31Rush yards against90.0 (900)6Points allowed20.0 (200)9Tampa Bay's Key PlayersOffenseIn 10 games played this year, has racked up 2,389 pa sing yards, while throwing 15 touchdowns against six interceptions and completing 64. Isaiah Dunn Jersey 6% of his pa ses.Mayfield has also rushed for 139 yards (second on the Buccaneers). has 780 receiving yards and seven touchdowns (third in the NFL) on 48 receptions, while being targeted 82 times. has rushed for four touchdowns this year, and has totaled 459 rushing yards (45.9 per game and 3.3 per carry).White's offensive output includes 41 receptions (4.1 per game) on 44 targets for 354 yards (35.4 per game) and one receiving touchdown. has been targeted 75 times, resulting in 50 catches for 561 yards .DefenseLavonte David has 3.0 sacks (fourth on the Buccaneers) to go with 14.0 TFL and 90 tackles through 10 games in 2023.. has one interception on top of 71 tackles, 2.0 TFL, two sacks, and seven pa ses defended. has intercepted one pa s on top of 62 tackles, 3.0 TFL, two sacks, and three pa ses defended during the 2023 campaign. season stats include 31 tackles, 8.0 TFL, and 5.5 sacks in nine games.